The Neonatal Information System™ (NIS™) High-Risk Infant Follow-Up System (HRF) is a clinical database solution that was developed based on over 25 years of input from physicians, nurses and administrators from different regions of the United States. Designed specifically for high-risk infants, the NIS™ HRF supports the tracking of health outcomes and neurodevelopment from infancy through childhood and encompasses the full scope of high-risk infant follow-up assessment and care.

The NIS™ HRF can be used as a standalone system or as an app to the NIS™. For hospitals using the NIS™, the demographic, perinatal, hospital stay and discharge data are automatically linked to the NISHRF, saving time and avoiding double data entry. In addition, new patient data (for patients whose hospital care occurred elsewhere) can also be entered into the NISHRF clinical database.

Hospitals that choose to use the NIS™ HRF as a standalone data management system have the option to interface with the hospital electronic medical record - just as the hospitals that use the in-house portion of the NIS™ has - to upload data to and from the EMR and NIS™ HRF.

Importantly, hospitals using the NIS™ High-Risk Infant Follow-up application able to query the data both retrospectively as well as prospectively. As an example:

Of the patients who had BPD and were on a ventilator for more than 10 days and received a FiO2 of greater than 0.75; how many were developmentally delayed at a corrected age of 18 months.


Of the patients who were developmentally delayed at age 18 months; how many had BPD and were on a ventilator of more than 10 days and received a FiO2 of greater than 0.75.